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Neuropathology
In the past the pathological study of the brain at post mortem revealed information upon which great advances in understanding the etiology of neurological and some mental disorders were based, leading to the German psychiatrist Wilhelm Griesinger's postulate: “all mental illness is disease of the brain.” The application of the principles of pathology to general paralysis of the insane, one of the most common conditions found in mental hospitals in the late 19th century, resulted in the discovery that this was a form of neurosyphilis and was caused by infection with the spirochete bacterium Treponema pallidum. The examination of the brains of patients with other forms of dementia has given useful information concerning other causes of this syndrome, for example, Alzheimer's disease and arteriosclerosis. The pinpointing of abnormalities of specific areas of the brain has aided understanding of some abnormal mental functions, such as disturbances of memory or speech disorders. However, no abnormal pathology has been demonstrated for most mental disorder.
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