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Cyclosporine

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Cyclosporine

Calcineurin inhibitors are the most effective immunosuppressive drugs in use. These drugs target intracellular signaling pathways induced by the activation of T lymphocytes (or T cells), a type of white blood cell that directly attacks and eliminates foreign molecules from the body. Cyclosporine and tacrolimus bind to different molecular targets, but both drugs inhibit calcineurin and, as a result, the function of T cells. Cyclosporine is used in patients who are undergoing kidney, liver, heart and other organ transplantation, and it is used for the treatment of rheumatoid arthritis and the skin disease psoriasis. Cyclosporine is usually used in combination with other agents, especially glucocorticoids. Tacrolimus is indicated for the prevention of graft rejection and as emergency therapy for transplant recipients who do not respond to cyclosporine.

Article ID: 97
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