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Probenecid and Colchicine
Probenecid and Colchicine are the Drugs used in the treatment of chronic gout, a disorder that is characterized by recurrent acute attacks of inflammation in one or more joints of the extremities. Probenecid stops the transport of most organic acids in the renal tubules of the kidneys. Originally It was used in medicine to prolong the action of the antibiotic penicillin by preventing its loss in the urine. In large doses, however, probenecid enhances the excretion of uric acid, the compound that accumulates in and about the joints in persons with gout. Continued administration of the drug in gouty arthritis shrinks solid uric acid deposits in the joints and reduces swelling in enlarged joints, thus restoring their mobility.
Side Effects of Colchicine
Colchicine is a drug used in the
treatment of gout, .
Colchicine is obtained from the autumn crocus (Colchicum autumnale).
The mechanism by which colchicine relieves the pain of gout, which is
caused by solid deposits of uric acid in the joints, the kidneys, and
other tissues, is unknown. Side effects include diarrhea and other
gastrointestinal disturbances.
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