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Connective Tissue Disease
Rheumatoid arthritis is a chronic disease in which a predominant nonsuppurative inflammation (an inflammation that does not discharge pus) of the peripheral joints often also manifests in ways not directly associated with the joints. These include blood-vessel inflammation in the form of tiny areas of necrosis in the fingertips; chronic leg ulcers and lesions in the peripheral nerves; inflammation of the pericardium and of the sclerae; inflammation and nodule formation in the lungs and pleura (tissue covering the lungs); anemia; enlargement of the lymph nodes; and Sjögren's, or sicca, syndrome (see below). The disease process within the joints begins as an inflammation of the synovium (joint-lining tissue). In most cases there is an increase, often considerable, in the amount of synovial (joint) fluid. Enlargement of the spleen occurs in approximately 5 percent of affected persons.
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