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Degenerative diseases
Degenerative diseases are characterized by progressive destruction of neurons without evident cause. Such diseases include Alzheimer disease, affecting primarily the cerebral cortex; Huntington and Parkinson diseases, affecting the basal ganglia and cortex; motor neuron disease, affecting the corticospinal tracts and ventral-horn cells; spinocerebellar degenerations, involving long tracts in the spinal cord, the cerebellum and its connections, and sometimes peripheral nerves; and the hereditary neuropathies with no known metabolic basis, in which motor, sensory, or both classes of peripheral nerves degenerate and lose their function. Most such diseases develop after a variable period during which that part of the nervous system subsequently affected apparently functions normally. As research progresses, the metabolic (and often genetic) bases of these diseases are being successively revealed.
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