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Symptoms of Rheumatic Fever
An inflammatory disease, primarily affecting the heart, joints, skin, and in some acute cases the central nervous system, that results from a delayed reaction to infection with group A beta-hemolytic streptococcal bacteria.
Rheumatic fever occurs chiefly in children and young adults, with a peak incidence between ages 5 and 15. Approximately 1 percent of individuals with recognized streptococcal infection will subsequently develop rheumatic fever.
The onset of the disease is most often characterized by the sudden occurrence of fever and joint pain and inflammation several days to six weeks after a streptococcal infection, usually of the throat. Signs of cardiac involvement include heart murmurs, increased heartbeat rate, and heart enlargement. Inflammation of the heart muscle and supporting structures may lead to a permanent scarring and contracture of the heart valves and a marked decrease in life expectancy. Other symptoms of rheumatic fever include nodules beneath the skin and skin rashes, the most typical of which is erythema marginatum; chorea, a nervous system manifestation marked by emotional instability and purposeless, involuntary movements of the arms and legs; abdominal pain; nosebleeds; weakness; and loss of appetite and body weight. Generally the clinical symptoms, severity, and aftereffects of an attack of rheumatic fever are highly variable, ranging from a condition so mild as to go unnoticed to a severe acute attack associated with cardiac failure and death.
During the course of rheumatic fever, the streptococcal organism may no longer be demonstrable in cultures of the throat or other infected body areas, but blood titres of antibodies against the streptococcus, such as antistreptolysin O, are high. All the numerous types of group A beta-hemolytic streptococcus appear capable of inducing rheumatic fever in susceptible individuals; infection with one type confers no immunity against the others, and individuals who have experienced one attack of rheumatic fever are especially prone to subsequent attacks.
The exact cause of rheumatic fever is not clear, although most authorities favour the theory that the disease results from an autoimmune reaction, involving the production of antibodies that attack the body's own tissues. The autoimmune reaction is believed to be triggered by components of the streptococci (antigens) whose structure resembles that of molecules found in human tissue (self antigens). Because of this resemblance, the antibodies that recognize streptococcal antigens may mistakenly react with similarly shaped antigens of certain cells of the body—such as those of the heart. By binding to these self antigens, the antibodies cause the tissue damage characteristic of rheumatic fever.
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