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Treatment of migraine
One basic therapeutic step in treating migraine is to determine which stimuli, if any, trigger the attacks, in order to avoid them in the future. Most of the remaining therapies involve the use of various medications.
Drug therapies for migraine consist of abortive measures, which aim at stopping or alleviating an attack as it is starting or soon afterward, and preventive measures, which involve daily doses of medications to reduce the intensity or frequency of migraine attacks or eliminate them altogether.
Aspirin, acetaminophen, and such nonsteroidal anti-inflammatory drugs as ibuprofen and naproxen are effective in aborting mild migraines.
Migraine attacks of greater severity can sometimes be treated at the start with ergotamine, sumatriptan, dihydroergotamine mesylate (DHE-45), or caffeine; all of these drugs enhance the effect or supply of serotonin within the brain. Certain other medications are used on a daily, long-term basis if migraines have become extremely painful or have reached a frequency of one per week.
These medications can mitigate the severity of such migraines and make them occur less frequently.
Among these medications are ergotamine; beta-adrenergic blocking agents (beta blockers), notably propranolol (Inderalä) and timolol (Blocadrenä); calcium channel blockers; and serotonin antagonists such as zolmitriptan (Zomigä), sumatriptan (Imitrexä), and methysergide (Sansertä).
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